What is KI 67 PROLIFERATION INDEX?
Antigen KI-67 is a nuclear protein that is associated with and may be necessary for cellular proliferation. Furthermore it is associated with ribosomal RNA transcription. ... (the Ki-67 labeling index) is often correlated with the clinical course of cancer.
http://en.wikipedia.org/wiki/Ki-67_(protein)
This study noted that a high index of Ki-67 usually means a poor prognosis (shorter survival), ... Proliferation Marker Ki-67 in Early Breast Cancer. Journal of Clinical Oncology, Vol 23, No 28 (October 1), 2005: pp. 7212-7220.
http://breastcancer.about.com/od/tumormarkers/f/ki67.htm
Prognostic Biomarkers - Ki-67 Proliferation Index Indications for use. Proliferation index is an important prognostic factor in breast cancer. The Ki-67 protein is expressed in all phases of the cell cycle except G0 and serves as a good marker for proliferation.
http://www.bcm.edu/breastcenter/pathology/index.cfm?pmid=11154
In soft tissue sarcomas Ki-67 index is positively correlated with mitotic count, cellularity and histological grade. In some ... the proliferative index measured by Ki67 immunoreactivity has both prognostic and predictive value. ...
http://www.nordiqc.org/Epitopes/ki67/ki67.htm
Ki-67 recognises a proliferation specific nuclear antigen 10. Immunohistochemical expression Ki-67 is expressed by proliferating cells in late G 1, S, ... Soft tissue sarcoma: Ki-67 index (the number of Ki-67-positive tumor cells/10 HPF) ...
http://www.e-immunohistochemistry.info/web/Ki-67.htm
Ki-67 and Other Markers of Proliferation. ... An index based on the Ki-67–apoptosis ratio (the cell turnover or growth index) has been developed to approximate the contribution that these two factors may make to tumor growth. While it is clear ...
http://jco.ascopubs.org/content/23/28/7212.full
The proliferative or growth fraction as determined by Ki67 analysis is interpreted in view of what is normal for the tissue in which the tumor has been found or from which it originated. ... How far from normal is the Ki-67 labeling index of my tumor?
http://www.answers.com/topic/ki67
Low Ki-67 proliferation index is an indicator of poor prognosis in gastric cancer JOURNAL OF SURGICAL ONCOLOGY, Issue 3 2010 Hee Eun Lee MD Abstract Background and Objectives We designed this study to assess the biologic significance of Ki-67 proliferation index (PI) in gastric cancer.
http://www.academicconcepts.net/concepts/474/ki67_proliferation_index.htm
Research article Evaluation of Ki-67 proliferation and apoptotic index before, during and after neoadjuvant chemotherapy for primary breast cancer
http://breast-cancer-research.com/content/8/3/r31
Vascular microinvasion and Ki-67 proliferative index are the most sensitive and specific factors for invasivity. High proliferating tumors that have a Ki-67 index higher than 10% are usually larger than 2 cm, have extensive angioinvasion, and show a great ...
http://erc.endocrinology-journals.org/content/14/2/221.full
1. Hum Pathol. 2012 Apr;43(4):489-95. doi: 10.1016/j.humpath.2011.06.011. Epub 2011 Sep 19. Ki-67 proliferative index predicts progression-free survival of patients with well-differentiated ileal neuroendocrine tumors.
http://www.ncbi.nlm.nih.gov/pubmed/21937080
proliferation, as measured by Ki-67 index, should be considered as a prognostic marker in clinical management of pleomorphic soft tissue sarcomas. PMID: 15309631. In multiple ...
http://www.antibodybeyond.com/reviews/antigen-k/ki67.htm
KI 67 PROLIFERATION INDEX DEFINITION Cancers as. Us national institute of. Labeled-cell count. Overestimation of. Key words thyroid cancer of. Sep.
http://avkon1.fatcow.com/2009website/27/ki-67-proliferation-index-definition
Janet, the Ki-67 proliferation index is a test they do to help grade your tumor. It helps measure how many of your cancer cells are growing very quickly.
http://www.healthcentral.com/breast-cancer/c/question/9938/33177
Correlation of Ki 67 proliferative index with clinical and pathological features on tissue sections of non Hodgkins lymphoma by immunostaining Erum Naz, Talat Mirza, Farheen Danish (Department of Pathology, DIMC, Karachi. ) Sina Aziz (SZLC, Civil Hospital ...
http://www.jpma.org.pk/full_article_text.php?article_id=2920
1. Appl Immunohistochem Mol Morphol. 2007 Jun;15(2):160-4. The significance of Ki-67 proliferative index and cyclin D1 expression of dysplastic nevi in the biologic spectrum of melanocytic lesions.
http://www.ncbi.nlm.nih.gov/pubmed/17525627
MIB-1 (KI-67) Proliferation Index and Cyclin-Dependent Kinase Inhibitor p27 Kip1 Protein Expression in Nephroblastoma
http://clincancerres.aacrjournals.org/content/10/2/591.full
What is Ki-67?. Dr. Susan Love Research Foundation provides comprehensive information about breast cancer, menopause, women's health, and ductal lavage. Intraductal research, grants, advocacy, and army of women focus on ending breast cancer.
http://www.dslrf.org/breastcancer/content.asp?L2=3&L3=7&PID=&sid=132&cid=1487
does anyone know about the scoring of : the proliferation Index Ki-67 ( MIB-1) - the results gives you a percentage, but I don't know what is a good, better, best, or worse %. Can you tell me ...
http://www.inspire.com/groups/advanced-breast-cancer/discussion/tumor-marker-4/
The aim of this study was to evaluate the role and prognostic significance of the Ki-67 proliferation index (PI) in non-Hodgkin's lymphoma. Ki-67 was assayed immunohistochemically in tissue samples of 319 patients with newly-diagnosed non-Hodgkin's lymphoma.
http://www.academicconcepts.net/concepts/474/ki67_index.htm
Soft tissue sarcomas (STSs) are heterogeneous neoplasms that have variable clinical outcome. Several clinical parameters and few molecular markers, including Ki-67 proliferative index, have been shown to correlate with patient prognosis.
http://onlinelibrary.wiley.com/doi/10.1002/1097-0142(20010815)92:4%3C869::AID-CNCR1395%3E3.0.CO;2-U/full
Evaluation of ER and Ki-67 proliferation index as prognostic factors for survival following neoadjuvant chemotherapy with doxorubicin/docetaxel for locally advanced breast cancer.
http://www.mendeley.com/catalog/evaluation-er-ki-67-proliferation-index-prognostic-factors-survival-following-neoadjuvant-chemothera/
... Ki-67 expression and novel proliferation markers phosphohistone H3 (PHH3), minichromosome maintenance protein 4 (MCM4) ... Microarrays of bladder cancer tissue are highly representative of proliferation index and histological grade. J Pathol 2001 ...
http://www.biomedcentral.com/1471-2407/10/140
The Ki67 proliferation index is a quantitative indicator of clinical risk in mantle cell lymphoma ... Teerenhovi L, Elonen E. Ki-67 expression level, histological subtype, and the International Prognostic Index as outcome predictors in mantle cell lymphoma. Eur J Haematol.
http://bloodjournal.hematologylibrary.org/content/107/8/3407.full
Best Answer: Ki67 antigen is the prototypic cell cycle related nuclear protein, expressed by proliferating cells in all phases of the active cell cycle (G1, S, G2 and M phase ...
http://answers.yahoo.com/question/index?qid=1006053007567
Ki-67 is a test that detects a protein that is important in cell growth in the nucleus of the cancer cells. If a cell is about to divide there is a lot of this protein present within the nucleus and this can be seen by a special staining technique with a microscope. The higher the number, the ...
http://her2support.org/her2-breast-cancer/tests-a-treatments/ki-67
The Ki-67 proliferation index. The Ki-67, a cell proliferation associated nuclear antigen, is found in cells in nearly all stages of the cell cycle and is therfore a direct indicator of the growth fraction.
http://www.thebreastcaresite.com/tbcs/NewlyDiagnosed/BeforeSurgery/UnderstandingYourPathologyReport.htm
embedded tissue sections are used.Ki-67 proliferative index is high in well and moderately differentiated non-mucinous adenocarcinomas in an early Dukes’ stage (A or B).On the other hand, Ki-67 proliferating activity is
http://www.ayubmed.edu.pk/JAMC/PAST/20-4/Uzma.pdf
Low Ki-67 PI was correlated with poorly differentiated histology (P = 0.034), an advanced T stage (P < 0.001), and lymph node metastasis (P = 0.011).
http://onlinelibrary.wiley.com/doi/10.1002/jso.21583/abstract
Titre du document / Document title High Ki-67 proliferative index predicts disease specific survival in patients with high-risk soft tissue sarcomas
http://cat.inist.fr/?aModele=afficheN&cpsidt=1118104
The proliferation index, ... Dowsett M. Proliferation marker Ki-67 in early breast cancer. J Clin Oncol. 2005;23(28):7212-7220. 13. Johannessen AL, Torp SH. The clinical value of Ki-67/MIB-1 labeling index in human astrocytomas. Pathol ...
http://www.millipore.com/userguides.nsf/a73664f9f981af8c852569b9005b4eee/cf74e438d2da62f485257615005b5e89/$FILE/HCS213%20REV%20B.pdf
Proliferative index (Ki-67) Linear regression univariate analysis revealed a significant positive correlation between Ki-67 and (V)DMSA uptake in early and late phases (r = 0.37 at 10 min, P = 0.038; r = 0.42 at 60 min, P = 0.018; Fig. 1). Simple ...
http://breast-cancer-research.com/content/6/2/R56
Summary. Ki-67 proliferative index (Ki-67 index) is suggested to be an important prognostic variable and is included as one of the grading parameters for neuroendocrine tumors.
http://www.sciencedirect.com/science/article/pii/S0046817711002838
The estimation of the Ki-67 index in human breast cancer tissue has been proven to be a useful prognostic tool.
http://www.medscape.com/medline/abstract/7633653
Assess tumor cell proliferation (analogous to flow cytometric S-phase fraction) Assess prognosis in patients with bladder, brain, breast, kidney, ... The clinical value of Ki-67/MIB-1 labeling index in human astrocytomas. Pathol Oncol Res. 2006;12:143-147. Stuart-Harris R, Caldas C, ...
http://www.questdiagnostics.com/hcp/intguide/jsp/showintguidepage.jsp?fn=Breast/TS_Ki-67.htm
Abstract. Purpose: Proliferative activity defined by Ki-67 staining index (SI) has been correlated with progression and prognosis in a number of malignant tumors including prostate cancer.
http://clincancerres.aacrjournals.org/content/10/12/4118.full
The number obtained through this examination is termed the S-phase, growth, or proliferative fraction. This information can play an important part in deciding the best treatment for a cancer patient. Precautions.
http://www.healthline.com/galecontent/ki67
(ii) Ki-67 as a marker of proliferation and its significance for Drug Discovery The Ki-67 antigen (Ki-67) is a classic marker of cellular proliferation and has ... The proliferation index, defined as the percentage of proliferating cells in a ...
http://www.millipore.com/userguides.nsf/a73664f9f981af8c852569b9005b4eee/71a163aee150f184852575ca00819316/$FILE/HCS205MAN.pdf
Complementary value of the Ki-67 proliferation index to the oncotype DX recurrence score. Gwin K, Pinto M, Tavassoli FA. Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, USA. katja.gwin@uchospitals.edu. Abstract.
http://community.breastcancer.org/forum/5/topic/765539
Wiesner et al reported that a Ki-67 proliferation index ≥20% was found to be associated with all of the prognostic factors that were tested (ER, PgR, HER2 and nuclear grade). They stated that for routine clinical purposes, ...
http://www.spandidos-publications.com/etm/1/5/747
Ki67 labeling index (Ki67 LI), the percentage Ki67 immunoreactive cells, is a measure of tumor proliferation, with important clinical relevance in breast cancer, and it is extremely important to standardize its evaluation.
http://www.diagnosticpathology.org/content/6/S1/S7
colon; The nuclear protein Ki-67 is a proliferation index, as it is expressed only by dividing cells
http://journals.lww.com/amjclinicaloncology/Fulltext/2004/02000/Ki_67_Proliferation_Index__Correlation_With.2.aspx
Prognostic significance of the Ki-67-associated proliferative antigen in aggressive non-Hodgkin's lymphomas: a prospective Southwest Oncology Group trial TP Miller, TM Grogan ... the proliferative index, clinical outcome, ...
http://bloodjournal.hematologylibrary.org/content/83/6/1460.abstract
microinvasion and Ki-67 proliferative index are the most sensitive and specific factors for invasivity. High proliferating tumors that have a Ki-67 index higher than 10% are usually larger than 2 cm, have extensive angioinvasion, and show a great potential to develop
http://erc.endocrinology-journals.org/content/14/2/221.full.pdf
Prognostic Values of Proliferative Markers ki-67 and repp86 in Breast Cancer ... The odds ratio (the mean chance of ki-67 labeling index > 10%, repp86 labeling index >10%) in patients with recurrence was 4 (CI = 0.2 – 76.5) for ki-67 and
http://www.ams.ac.ir/AIM/07101/008.pdf
Breast Center Pathology Laboratory Baylor College of Medicine Houston, Texas Assay for Ki-67 Proliferation Index Important Procedural Notes:
http://www.bcm.edu/breastcenter/pathology/index.cfm?pmid=11155
Vol. 61, No. 8, August 2011 748 Original Article Correlation of Ki 67 proliferative index with clinical and pathological features on tissue sections of non Hodgkins
http://www.jpma.org.pk/PdfDownload/2920.pdf
Expression of proliferation index marker Ki-67 in the nuclear area of the tumor cells were examined using immuno-histochemistry. The labeled-cell count (Ki-67 proliferation index) was determined in ten high-power fields by two blinded observers. Ki-67 proliferation ...
http://www.jeccr.com/content/29/1/25
Proliferative index using Ki-67 index in reactive mesothelial versus metastatic adenocarcinoma cells in serous fluid Noushin Afshar Moghaddam 1, Alireza Rahmani 2, Diana Taheri 1, Mojtaba Mokhber Desfuli 1
http://www.advbiores.net/text.asp?2012/1/1/29/98155
Litofsky NS, Mix TC, Baker SP, Recht LD, Smith TW: Ki-67 (clone MIB-1) proliferation index in recurrent glial neoplasms: no prognostic significance. Surg Neurol 50:579–585, 1998. 33. McDonald JD, Rosenblum ML: Gliomas, in Wilkins RH, Rengachary SS (eds): Principles of Neurosurgery.
http://www.virtualtrials.com/pdf/The%20Ki-67.doc
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